Featured Review: Rufinamide add-on therapy for refractory epilepsy

This Review from Cochrane Epilepsy found six clinical trials that included in analysis 1759 people with focal epilepsy. These trials were all randomised controlled trials (clinical studies where people were randomly put into one of two or more treatment groups) that compared the antiepileptic drug rufinamide (at doses between 200 mg per day and 3200 mg per day) plus a conventional antiepileptic medicine to a placebo (pretend tablet) plus a conventional epileptic medicine for up to 96 days.

The review found that rufinamide, used in combination with other antiepileptic drugs in people who had drug-resistant focal epilepsy decreased the frequency of seizures further. The review also showed that rufinamide seemed to be associated with more side effects such as dizziness, tiredness, headache, double vision, nausea and vomiting compared to placebo but more information is needed about some of these events.